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Bioengineering Rehabilitation for Wounded

Method found to attract endogenous stem cells for healing bone lesions

It has been proven that topical application of statins leads to better healing of bone defects, although the mechanism of therapeutic action has not yet been determined.
Chinese scientists from the Third Hospital of Beijing University performed a study to assess the local impact of symvastatin on healing bone defects, and evaluate the impact of symvastatin on mobilization, migration and homing mesenchymal stem cells (MSCs) bone marrow and endothelial progenitor cells (EPCs ).
It was found that the topical application of simvastatin increases bone tissue formation by 51.8% after six weeks and 64.8% after 12 weeks compared with controls (polyglycolic acid). This information was confirmed by histological examination, computed tomography and X-ray examination.
Simvastatin increased migration ability of BMSCs and EPCs in vitro. When applied topically simvastatin by 127% increased the mobilization of EPCs in peripheral blood (confirmed by FACS analysis). In addition, significantly increased blood concentrations of osteogenic BMSCs, which was confirmed by Alizarin red staining.
Genetic labeling BMSCs with green fluorescent protein (GFP) has allowed for following the transplanted cells and showed that simvastatin implant attracts labeled BMSCs. In addition, simvastatin stimulated the expression of HIF-1α and BMP-2.
Thus, the results showed that the local implantation of simvastatin stimulates healing of the bone defect. The basis of this effect is increased expression of HIF-1α BMP-2, leading to the involvement of endogenous angiogenic and osteogenic stem cells to the area of the bone defect.

This material is presented in the following article: http://www.ncbi.nlm.nih.gov/pubmed/24016857

Remember as part of the project Bioengineering Rehabilitation for Wounded, doctors at ilaya Medical Company are using the latest in biotechnology to restore the damaged limbs of Ukrainian military personnel. Currently ongoing is fundraising to treat 10 wounded under the project. Biotechnology presents the only chance for them to return to normal life. Please join the project and support Ukraine’s defenders.

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Bioengineering Rehabilitation for Wounded

Regeneration of bone and tissue loss, sustained through mechanical or gunshot wounds through application of ilaya.regeneration stem cell technology

30 520 391 UAH (834 606 USD) needed
100% raised
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Реквізити ПриватБанку для переказу у гривнях
Миколаївський обласний благодійний фонд “РЕГІОНАЛЬНИЙ ФОНД БЛАГОЧЕСТЯ”
ПАО КБ ПриватБанк
ЄДРПОУ: 36143302
МФО: 305299
IBAN-код:
Призначення платежу: Благодійний внесок. “”
USD
Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBANcode: UA583052990000026007011702069
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: JP Morgan Chase Bank,New York ,USA
Swift code: CHASUS33
Correspondent account: 001-1-000080
Description: Charitable donation for ‘’ project
or
Intermediary bank: The Bank of New York Mellon, New York, USA
Swift code: IRVT US 3N
Correspondent account: 890-0085-754
Description: Charitable donation for ‘’ project
EUR
Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBANcode: UA703052990000026002041702959
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: Commerzbank AG ,Frankfurt am Main, Germany
Swift code: COBADEFF
Correspondent account: 400886700401
Description: Charitable donation for ‘’ project
PLZ
Beneficiary: Mykolayiv Regional Charitable Foundation "Regional Foundation Blagochestya"
IBAN Code: UA363052990000026006001705679
Name of the bank: JSC CB "PRIVATBANK", 1D HRUSHEVSKOHO STR., KYIV, 01001, UKRAINE
Bank SWIFT Code: PBANUA2X
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
CORRESPONDENT BANK: Bank Pekao/Grupa Pekao S.A., Warsaw, Poland
Account in the correspondent bank: PL13124000013140533111120301
SWIFT Code of the correspondent bank: PKOPPLPW
Description: Charitable donation for "" project.
GBP
Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBANcode: UA583052990000026007011702069
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: JP Morgan Chase Bank,New York ,USA
Swift code: CHASUS33
Correspondent account: 001-1-000080
Description: Charitable donation for ‘’ project
or
Intermediary bank: The Bank of New York Mellon, New York, USA
Swift code: IRVT US 3N
Correspondent account: 890-0085-754
Description: Charitable donation for ‘’ project

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