Bioengineering Rehabilitation for Wounded

April 14, 2016

Method found to attract endogenous stem cells for healing bone lesions

Method found to attract endogenous stem cells for healing bone lesions

It has been proven that topical application of statins leads to better healing of bone defects, although the mechanism of therapeutic action has not yet been determined.
Chinese scientists from the Third Hospital of Beijing University performed a study to assess the local impact of symvastatin on healing bone defects, and evaluate the impact of symvastatin on mobilization, migration and homing mesenchymal stem cells (MSCs) bone marrow and endothelial progenitor cells (EPCs ).
It was found that the topical application of simvastatin increases bone tissue formation by 51.8% after six weeks and 64.8% after 12 weeks compared with controls (polyglycolic acid). This information was confirmed by histological examination, computed tomography and X-ray examination.
Simvastatin increased migration ability of BMSCs and EPCs in vitro. When applied topically simvastatin by 127% increased the mobilization of EPCs in peripheral blood (confirmed by FACS analysis). In addition, significantly increased blood concentrations of osteogenic BMSCs, which was confirmed by Alizarin red staining.
Genetic labeling BMSCs with green fluorescent protein (GFP) has allowed for following the transplanted cells and showed that simvastatin implant attracts labeled BMSCs. In addition, simvastatin stimulated the expression of HIF-1α and BMP-2.
Thus, the results showed that the local implantation of simvastatin stimulates healing of the bone defect. The basis of this effect is increased expression of HIF-1α BMP-2, leading to the involvement of endogenous angiogenic and osteogenic stem cells to the area of the bone defect.

This material is presented in the following article: http://www.ncbi.nlm.nih.gov/pubmed/24016857

Remember as part of the project Bioengineering Rehabilitation for Wounded, doctors at ilaya Medical Company are using the latest in biotechnology to restore the damaged limbs of Ukrainian military personnel. Currently ongoing is fundraising to treat 10 wounded under the project. Biotechnology presents the only chance for them to return to normal life. Please join the project and support Ukraine’s defenders.

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Bioengineering Rehabilitation for Wounded

15508 people

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30 015 455 UAH (1 086 137 USD)

of 30 441 922 UAH (1 101 568 USD) needed

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Updated 27.12.2018 at 16:56
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Requisites of the project Bioengineering Rehabilitation for Wounded

PrivatBank for UAH transfers

Mykolaiv regional charitable foundation “BLAGOCHESTYA REGIONAL FUND”
PC CB PrivatBank
USREOU: 36143302
MFO: 326610
Account: 26004053210825
Purpose of payment: charity donation. Bioengineering rehabilitation for wounded

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Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBAN­code: UA803266100000026009053209659
Account: 26009053209659
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: JP Morgan Chase Bank,New York ,USA
Swift code: CHASUS33
Correspondent account: 001-­1­-000080
Description: Charitable donation for ‘Bioengineering rehabilitation for wounded’ project.
or
Intermediary bank: The Bank of New York Mellon, New York, USA
Swift code: IRVT US 3N
Correspondent account: 890-­0085-­754
Description: Charitable donation for ‘Bioengineering rehabilitation for wounded’ project.

SWIFT-transfer in EUR

Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBAN­code: UA413266100000026009053206287
Account: 26009053206287
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: Commerzbank AG ,Frankfurt am Main, Germany
Swift code: COBADEFF
Correspondent account: 400886700401
Description: Charitable donation for ‘Bioengineering rehabilitation for wounded’ project.


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