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Bioengineering Rehabilitation for Wounded

Multiple sclerosis cure: “reset” immune system

Canadian researchers have reported successful clinical trials of the treatment of multiple sclerosis with hematopoietic stem cells. The report on the work was published in the journal The Lancet.

Multiple sclerosis is a chronic autoimmune disease that causes damage to the myelin membrane of nerve fibers in different parts of the central nervous system that leads to the disruption of nerve transmission and loss of relevant features (sensory, motor, and so on).

In non-randomized open trial, conducted by the University of Ottawa, Canada, under the direction of Harold Atkins with colleagues from other scientific and clinical centers, 24 patients aged 18 to 50 years with steady to treatment of aggressive course of multiple sclerosis and poor prognosis participated. During the time from diagnosis to transplantation in total there were 167 exacerbations of the disease over 140 patients and 188 specific brain tissue lesions were found on MRI.

During the experimental treatment, participants took cells of the predecessor hematopoiesis (CD34 +) and underwent immuno-ablation (destruction of immune cells) of busulfan, cyclophosphamide and antytymotsytarnym rabbit immunoglobulin. After this immunity was restored transplantation patients own cells took place. The purpose of this was to destroy a population of immune cells that attack myelin fibers and other structures of the nervous system of patients.

The observation of patients lasted an average of 6.7 years (from 3.9 to 12.7 years). Within three years of treatment (primary endpoint test) at 69.9 percent volunteer signs of multiple sclerosis activity was not observed (worsening, progression and brain damage visible on MRI with gadolinium contrast). During the time of observation in any of those participants who survived, there was no clinical exacerbations of the disease or need for specific therapy and the rate of brain atrophy diminished to the level of a healthy person.

In 35 percent of volunteers expression of disability (as enlarged scale organic disorders) associated with blurred vision, muscle weakness and impaired coordination steadily decreased. Several participants were able to return to work or study.

Despite the overall success of the experimental treatment there were severe complications. One of the patients died of infectious liver damage as a result of immuno-ablation, another patient with the same condition needed to be placed in the intensive care unit. Fever was observed in all participants in the treatment.

As the researchers write, the technique is the first type of treatment that has completely stopped inflammatory activity in the central nervous system in patients with multiple sclerosis for a long time and with no additional therapy. They also note that further testing is necessary to specify a group of patients undergoing such treatment that will bring maximum benefit at low risk of complications.

As a reminder, as part of the project Bioengineering Rehabilitation for Wounded iLaya clinic doctors, using the latest biotechnology, restore the damaged limbs of wounded Ukrainian soldiers. The People’s Project reported the sensational recovery of the foot 19-year-old wounded volunteer.

Currently the collection of funds for the treatment of two wounded continues and five more are waiting in line to join the project. For them biotechnology represents the only chance of recovery. Please get involved and help Ukraine’s defenders.

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Bioengineering Rehabilitation for Wounded

Regeneration of bone and tissue loss, sustained through mechanical or gunshot wounds through application of ilaya.regeneration stem cell technology

30 520 391 UAH (834 606 USD) needed
100% raised
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Реквізити ПриватБанку для переказу у гривнях
Миколаївський обласний благодійний фонд “РЕГІОНАЛЬНИЙ ФОНД БЛАГОЧЕСТЯ”
ПАО КБ ПриватБанк
ЄДРПОУ: 36143302
МФО: 305299
IBAN-код:
Призначення платежу: Благодійний внесок. “”
USD
Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBANcode: UA583052990000026007011702069
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: JP Morgan Chase Bank,New York ,USA
Swift code: CHASUS33
Correspondent account: 001-1-000080
Description: Charitable donation for ‘’ project
or
Intermediary bank: The Bank of New York Mellon, New York, USA
Swift code: IRVT US 3N
Correspondent account: 890-0085-754
Description: Charitable donation for ‘’ project
EUR
Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBANcode: UA703052990000026002041702959
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: Commerzbank AG ,Frankfurt am Main, Germany
Swift code: COBADEFF
Correspondent account: 400886700401
Description: Charitable donation for ‘’ project
PLZ
Beneficiary: Mykolayiv Regional Charitable Foundation "Regional Foundation Blagochestya"
IBAN Code: UA363052990000026006001705679
Name of the bank: JSC CB "PRIVATBANK", 1D HRUSHEVSKOHO STR., KYIV, 01001, UKRAINE
Bank SWIFT Code: PBANUA2X
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
CORRESPONDENT BANK: Bank Pekao/Grupa Pekao S.A., Warsaw, Poland
Account in the correspondent bank: PL13124000013140533111120301
SWIFT Code of the correspondent bank: PKOPPLPW
Description: Charitable donation for "" project.
GBP
Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBANcode: UA583052990000026007011702069
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: JP Morgan Chase Bank,New York ,USA
Swift code: CHASUS33
Correspondent account: 001-1-000080
Description: Charitable donation for ‘’ project
or
Intermediary bank: The Bank of New York Mellon, New York, USA
Swift code: IRVT US 3N
Correspondent account: 890-0085-754
Description: Charitable donation for ‘’ project

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