Bioengineering Rehabilitation for Wounded

July 08, 2016

Multiple sclerosis cure: “reset” immune system

Multiple sclerosis cure: “reset” immune system

Canadian researchers have reported successful clinical trials of the treatment of multiple sclerosis with hematopoietic stem cells. The report on the work was published in the journal The Lancet.

Multiple sclerosis is a chronic autoimmune disease that causes damage to the myelin membrane of nerve fibers in different parts of the central nervous system that leads to the disruption of nerve transmission and loss of relevant features (sensory, motor, and so on).

In non-randomized open trial, conducted by the University of Ottawa, Canada, under the direction of Harold Atkins with colleagues from other scientific and clinical centers, 24 patients aged 18 to 50 years with steady to treatment of aggressive course of multiple sclerosis and poor prognosis participated. During the time from diagnosis to transplantation in total there were 167 exacerbations of the disease over 140 patients and 188 specific brain tissue lesions were found on MRI.

During the experimental treatment, participants took cells of the predecessor hematopoiesis (CD34 +) and underwent immuno-ablation (destruction of immune cells) of busulfan, cyclophosphamide and antytymotsytarnym rabbit immunoglobulin. After this immunity was restored transplantation patients own cells took place. The purpose of this was to destroy a population of immune cells that attack myelin fibers and other structures of the nervous system of patients.

The observation of patients lasted an average of 6.7 years (from 3.9 to 12.7 years). Within three years of treatment (primary endpoint test) at 69.9 percent volunteer signs of multiple sclerosis activity was not observed (worsening, progression and brain damage visible on MRI with gadolinium contrast). During the time of observation in any of those participants who survived, there was no clinical exacerbations of the disease or need for specific therapy and the rate of brain atrophy diminished to the level of a healthy person.

In 35 percent of volunteers expression of disability (as enlarged scale organic disorders) associated with blurred vision, muscle weakness and impaired coordination steadily decreased. Several participants were able to return to work or study.

Despite the overall success of the experimental treatment there were severe complications. One of the patients died of infectious liver damage as a result of immuno-ablation, another patient with the same condition needed to be placed in the intensive care unit. Fever was observed in all participants in the treatment.

As the researchers write, the technique is the first type of treatment that has completely stopped inflammatory activity in the central nervous system in patients with multiple sclerosis for a long time and with no additional therapy. They also note that further testing is necessary to specify a group of patients undergoing such treatment that will bring maximum benefit at low risk of complications.

As a reminder, as part of the project Bioengineering Rehabilitation for Wounded iLaya clinic doctors, using the latest biotechnology, restore the damaged limbs of wounded Ukrainian soldiers. The People’s Project reported the sensational recovery of the foot 19-year-old wounded volunteer.

Currently the collection of funds for the treatment of two wounded continues and five more are waiting in line to join the project. For them biotechnology represents the only chance of recovery. Please get involved and help Ukraine’s defenders.

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Altogether on the project

Bioengineering Rehabilitation for Wounded

15511 people

donated

30 016 654 UAH (1 086 180 USD)

of 30 441 922 UAH (1 101 568 USD) needed

98% raised

Updated 27.12.2018 at 16:56
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Project manager

save live & ilaya and mykolaiv fond eng

Requisites of the project Bioengineering Rehabilitation for Wounded

PrivatBank for UAH transfers

Mykolaiv regional charitable foundation “BLAGOCHESTYA REGIONAL FUND”
PC CB PrivatBank
USREOU: 36143302
MFO: 326610
Account: 26004053210825
Purpose of payment: charity donation. Bioengineering rehabilitation for wounded

SWIFT-transfer in USD

Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBAN­code: UA803266100000026009053209659
Account: 26009053209659
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: JP Morgan Chase Bank,New York ,USA
Swift code: CHASUS33
Correspondent account: 001-­1­-000080
Description: Charitable donation for ‘Bioengineering rehabilitation for wounded’ project.
or
Intermediary bank: The Bank of New York Mellon, New York, USA
Swift code: IRVT US 3N
Correspondent account: 890-­0085-­754
Description: Charitable donation for ‘Bioengineering rehabilitation for wounded’ project.

SWIFT-transfer in EUR

Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBAN­code: UA413266100000026009053206287
Account: 26009053206287
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: Commerzbank AG ,Frankfurt am Main, Germany
Swift code: COBADEFF
Correspondent account: 400886700401
Description: Charitable donation for ‘Bioengineering rehabilitation for wounded’ project.


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