Bioengineering Rehabilitation for Wounded

July 28, 2016

Gene involved in healing fractures opened

Gene involved in healing fractures opened

A team of scientists from Lawrence Livermore National Laboratory (LLNL) in the US have identified a gene regulator of stem cells are involved in the healing of fractures. The discovery will help to develop new therapeutic treatments for injuries that are difficult to treat. Results of the research have been published in the “The Bone Journal”.
Regeneration of fractures involves the healing of bones, muscles, blood vessels and the thin shell of bone (periosteum). The periosteum contains stem cells that migrate to the site of injury and differentiate into chondrocytes (cartilage forming) or osteoblasts (bone forming).

To this day the interaction between stem cells and periosteum cells in the treatment of bone fractures has been little studied. The team of scientists from LLNL and Indiana University, opened Sostdc1 – gene regulator of stem cell activity in the recovery of fractures. The study showed that Sostdc1 plays a critical role in self-renewal and differentiation of stem cells that can be used in the development of new therapeutics for fractures that are difficult to treat.
There are two types of bone: cortical – dense and hard tissue that acts as the outer layer of most bones; and spongy, which is located at the ends of long bones near the joints and in the vertebrae.

The study found that mutant mice lacking the gene Sostdc1, despite lower trabecular bone density had thicker and more dense cortical layer of bone, which was restored after changing in less time compared to genetically normal counterparts.
In addition, the researchers showed that gene suppression of Sostdc1 induces a proliferation of stem cell populations and their migration to the site of injury, accelerating regeneration.
Earlier studies have found a gene involved in embryo implantation of Sostdc1, led to the formation of teeth and hair follicles and in the development of kidney disease progression and cancer.
“Our work describes previously unstudied gene function Sostdc1, emphasizing its potential role in metabolism and restoring the skeleton,” Gaby Loots, LLNL biologist and lead author of the article, said.

The study showed that Sostdc1 plays an important role in the shaping and the restoration of the spongy bone in the early stages of recovery after crisis, and its absence affects the behavior of stem cells in response to injury.
“Our research will further improve the performance of stem cells in other tissues,” LLNL biologist Nicole Collette, first author of the paper, said.

Earlier, The People’s Project reported the incredible restoration of the bone in a 19-year-old’s leg. Recently doctors formed new bone in a wounded soldier from the “Donbas” Battalion.

In the project Bioengineering Rehabilitation for Wounded, iLaya clinic doctors are using the latest biotechnology restore the damaged limbs of wounded Ukrainian soldiers.

Currently the collection of funds for the treatment of five wounded is underway and four more are waiting in line to join the project. For them biotechnology represents their only chance for recovery. Since the state, through legislative and other restrictions, can not support biotechnology in the treatment of wounded soldiers, their only hope lies with people.

We ask you to get involved and help Ukraine’s defenders.

Comments

Altogether on the project

Bioengineering Rehabilitation for Wounded

15609 people

donated

30 109 564 UAH (1 089 542 USD)

of 30 520 391 UAH (1 104 408 USD) needed

98% raised

Updated 27.12.2018 at 16:56
Share on Facebook

Project manager

save live & ilaya and mykolaiv fond eng

Requisites of the project Bioengineering Rehabilitation for Wounded

PrivatBank for UAH transfers

Mykolaiv regional charitable foundation “BLAGOCHESTYA REGIONAL FUND”
PC CB PrivatBank
USREOU: 36143302
MFO: 326610
Account: 26004053210825
Purpose of payment: charity donation. Bioengineering rehabilitation for wounded

SWIFT-transfer in USD

Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBAN­code: UA803266100000026009053209659
Account: 26009053209659
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: JP Morgan Chase Bank,New York ,USA
Swift code: CHASUS33
Correspondent account: 001-­1­-000080
Description: Charitable donation for ‘Bioengineering rehabilitation for wounded’ project.
or
Intermediary bank: The Bank of New York Mellon, New York, USA
Swift code: IRVT US 3N
Correspondent account: 890-­0085-­754
Description: Charitable donation for ‘Bioengineering rehabilitation for wounded’ project.

SWIFT-transfer in EUR

Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBAN­code: UA413266100000026009053206287
Account: 26009053206287
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: Commerzbank AG ,Frankfurt am Main, Germany
Swift code: COBADEFF
Correspondent account: 400886700401
Description: Charitable donation for ‘Bioengineering rehabilitation for wounded’ project.


Press about us

  • Новинарня
  • UA:українське радіо
  • UA|TV
  • 112 Україна
  • Радіо Свобода
  • УКМЦ
  • Український тиждень
  • Головне управління розвідки МО України
  • УНІАН
  • Ліга.НОВОСТИ
  • Depo UA
  • Інтер
  • Українська Правда
  • Styler РБК-Україна
  • 5 канал
  • Обозреватель
  • Новое время
  • ЦЕНЗОР.НЕТ
  • Bloomberg
  • FOX NEWS
  • Forbes
  • thequardian
  • 1+1 media
  • ictv
  • Украина
  • Еспресо TV
  • Громадське
  • НОВИНИ 24
  • “ЧАС”
  • zik
  • Журнал Житомира
  • СЕГОДНЯ.ua
  • ain
  • ZN,UA
  • delo.ua
  • inforesist
  • NEWSru.com
  • О.П.А.D
  • Вчасно
  • СОЦПОРТАЛ
  • Укрпогляд
  • tribuna
  • cimic
  • комсомольская правДА!

Partners