Bioengineering Rehabilitation for Wounded

September 14, 2016

Scientific first; inner ear tissue regenerated from stem cells

Scientific first;  inner ear tissue regenerated from stem cells

Previously, scientists could not grow inner ear hair cells in a laboratory, because of the horizontal cell culture there were no incentives needed for the formation of hair. To create a natural environment, a research group led by Karl R Koehler and Dr Eri Hashino from the College of Medicine of the University of Indiana (USA) used a three-dimensional culture system, described in an article on the site Nature Protocols.

In a 3D culture that mimics the conditions of the inner ear during embryonic development, the cells are in a “suspended” state and this provides the most comfortable conditions for the formation of the complex tissues and structures of the inner ear. Experimenting with different signaling molecules and proteins derived from mouse embryos, the researchers were able to stimulate the differentiation of stem cells into the precursor cells of the inner ear. During the week of cells formed aggregates structure strikingly similar to the embryo of the developing ear. Further changes in tissue that formed, were reminiscent of the development of the inner ear. After 16 days, researchers found hair-like cells. They play a key role in maintaining balance and converting sound into electrical signals that are perceived by the brain. Fully-grown hair cells generated electrical signals similar to the signals of the full body. They also form ties called synapses, with adjacent neurons  responsible for the transmission of signals from the inner ear to the brain.

Conducted electrophysiological tests confirmed that the obtained hair cells were fully functional and identical to the cells that are responsible for movement and gravity. “We were surprised that once stem cells turned into progenitor cells of the inner ear, and were placed in a three-dimensional environment, they behaved as if knew not only what types of cells of the inner ear differentiate, but also how to organize themselves in a structure, strangely similar to the natural inner ear,” Hashino said.

“The 3D culture allows cells to organize themselves into complex tissue by creating the mechanical signals that occur during embryonic development,” Koahler said. This study can be used to study the mechanisms of the inner ear and help to develop new modern methods of medical treatment and stem cell therapy for the treatment of inner ear.

Ukraine also has made great achievements in the development and application of advanced biotechnology. With its help Ukrainian specialists grown bone and nerve cells. This technology is used to restore damaged joints and limbs in wounded ATO soldiers, returning them to function and mobility. This technology is available at only a few clinics throughout the world, including Ukraine. Ilaya Medical Company and The People’s Project, under the Bioengineering Rehabilitation for Wounded,” restores injury in seriously wounded soldiers and returns them to a healthy life.

Earlier, The People’s Project reported using biotechnology to save an arm from amputation. And recently doctorsregrew bone in the leg of a wounded soldier from the “Donbas” Battalion.

Currently collection of funds for the treatment of five wounded is underway, while four more are waiting in line to join the project. For them, biotechnology – represents the only chance to recover. Since the state, through legislative and other restrictions, can not support biotechnology in the treatment of wounded soldiers their only hope lies with receiving donations from people.

Get involved and help Ukraine’s defenders.

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Altogether on the project

Bioengineering Rehabilitation for Wounded

15519 people

donated

30 023 299 UAH (1 086 420 USD)

of 30 441 922 UAH (1 101 568 USD) needed

98% raised

Updated 27.12.2018 at 16:56
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Project manager

save live & ilaya and mykolaiv fond eng

Requisites of the project Bioengineering Rehabilitation for Wounded

PrivatBank for UAH transfers

Mykolaiv regional charitable foundation “BLAGOCHESTYA REGIONAL FUND”
PC CB PrivatBank
USREOU: 36143302
MFO: 326610
Account: 26004053210825
Purpose of payment: charity donation. Bioengineering rehabilitation for wounded

SWIFT-transfer in USD

Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBAN­code: UA803266100000026009053209659
Account: 26009053209659
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: JP Morgan Chase Bank,New York ,USA
Swift code: CHASUS33
Correspondent account: 001-­1­-000080
Description: Charitable donation for ‘Bioengineering rehabilitation for wounded’ project.
or
Intermediary bank: The Bank of New York Mellon, New York, USA
Swift code: IRVT US 3N
Correspondent account: 890-­0085-­754
Description: Charitable donation for ‘Bioengineering rehabilitation for wounded’ project.

SWIFT-transfer in EUR

Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBAN­code: UA413266100000026009053206287
Account: 26009053206287
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: Commerzbank AG ,Frankfurt am Main, Germany
Swift code: COBADEFF
Correspondent account: 400886700401
Description: Charitable donation for ‘Bioengineering rehabilitation for wounded’ project.


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