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Bioengineering Rehabilitation for Wounded

Scientists discover gene that triggers development of scoliosis

Japanese scientists have identified a gene called hyperactive ladybird homeobox 1 (LBX1), which runs a genetic chain reaction that causes the spine to grow abnormally, thus contributing to scoliosis.
“Studies such as this, which define genes responsible for the development of scoliosis can help further develop a genetic test to detect scoliosis before symptoms appear,” study author Professor Chisa Shukunami from the University of Hiroshima said.

The researchers conducted genetic experiments using zebrafish. They genetically modified the fish so they had too much LBX1, and then watched as they grew.
The results showed in the zebrafish embryos, in which were introduced the additional LBX1 gene, cells responsible for the development of the spine and back muscles were wider than in healthy fish. In the fish that lived long enough, the bones in the back were deformed, leading to the development of scoliosis. Researchers believe that this model is a version of congenital scoliosis in humans.

Another group of zebrafish were genetically modified to carry additional genes expressing LBX1 throughout their lives, but only in certain cells. Some of these fish evolved with bones in their correct form, but as they matured, they started distorting the spine. This pattern is typical for most cases of scoliosis in humans as curvature of the spine occurs just before or during adolescence.

Adolescent idiopathic scoliosis affects 2-4% of children aged 10 to 16 years. Most often it occurs in girls.
During the experiments, the researchers found that scoliosis more often developed in female zebrafish rather than in males. The reasons for this phenomenon remains a mystery.
“A deeper understanding of the genetic mechanisms that lead to the development of adolescent scoliosis, will help us to develop genetic tests to detect the disease,” Shukunami said.

The study was published in the journal “PLOS Genetics”.
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1005802

Advanced biotech technology exists in Ukraine. Unfortunately, we tend to think that good clinics, advanced technology and professional doctors only exist abroad. While, the medical system in Ukraine is far from ideal in general, and we must lose this inferiority complex because is not necessary to go far to get expert help of professionals. The Bioengineering Rehabilitation for Wounded project for the past 18 months has proven it. For the wounded soldiers this advanced technology is the only way to avoid disability and physical limitations. And it is here in Ukraine we can provide this assistance. The number of men who have been put on their feet, by the project doctors is growing. However there are many more wounded military personnel in need of this medical care which can not be provided in public institutions, or even abroad. So once again we ask you to get involved in fundraising to support wounded Ukrainian military personnel.

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Bioengineering Rehabilitation for Wounded

Regeneration of bone and tissue loss, sustained through mechanical or gunshot wounds through application of ilaya.regeneration stem cell technology

30 520 391 UAH (834 606 USD) needed
100% raised
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Реквізити ПриватБанку для переказу у гривнях
Миколаївський обласний благодійний фонд “РЕГІОНАЛЬНИЙ ФОНД БЛАГОЧЕСТЯ”
ПАО КБ ПриватБанк
ЄДРПОУ: 36143302
МФО: 305299
IBAN-код:
Призначення платежу: Благодійний внесок. “”
USD
Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBANcode: UA583052990000026007011702069
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: JP Morgan Chase Bank,New York ,USA
Swift code: CHASUS33
Correspondent account: 001-1-000080
Description: Charitable donation for ‘’ project
or
Intermediary bank: The Bank of New York Mellon, New York, USA
Swift code: IRVT US 3N
Correspondent account: 890-0085-754
Description: Charitable donation for ‘’ project
EUR
Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBANcode: UA703052990000026002041702959
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: Commerzbank AG ,Frankfurt am Main, Germany
Swift code: COBADEFF
Correspondent account: 400886700401
Description: Charitable donation for ‘’ project
PLZ
Beneficiary: Mykolayiv Regional Charitable Foundation "Regional Foundation Blagochestya"
IBAN Code: UA363052990000026006001705679
Name of the bank: JSC CB "PRIVATBANK", 1D HRUSHEVSKOHO STR., KYIV, 01001, UKRAINE
Bank SWIFT Code: PBANUA2X
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
CORRESPONDENT BANK: Bank Pekao/Grupa Pekao S.A., Warsaw, Poland
Account in the correspondent bank: PL13124000013140533111120301
SWIFT Code of the correspondent bank: PKOPPLPW
Description: Charitable donation for "" project.
GBP
Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBANcode: UA583052990000026007011702069
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: JP Morgan Chase Bank,New York ,USA
Swift code: CHASUS33
Correspondent account: 001-1-000080
Description: Charitable donation for ‘’ project
or
Intermediary bank: The Bank of New York Mellon, New York, USA
Swift code: IRVT US 3N
Correspondent account: 890-0085-754
Description: Charitable donation for ‘’ project

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