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Bioengineering Rehabilitation for Wounded

Scientists make breakthrough in treatment of diabetes with stem cells from adipose tissue

Scientists at the Swiss Higher Technical School of Zurich (Eidgenössische Technische Hochschule Zürich, ETH Zürich) by means of genetic reprogramming of stem cell adipose tissue obtained beta cells that are virtually identical to natural. This study may be one of the most important steps in the personalized treatment of diabetes. The results of the experiments were published on April 11, 2016 by Nature Communications.

A team led by Martin Fussenegger, professor of biotechnology, and the Biosystems Science and Technology bioengineering department at ETH Zurich in Basel, conducted an experiment that to date has not been matched by anyone. The experts removed stem cells from the adipose tissue of a 50-year-old experimental patient and reprogrammed them to differentiate into functional beta cells.

In the presence of glucose, the beta cells resulting from an artificially created “genetic program”, produce the hormone insulin as well as the natural cells of the pancreas.
Researchers from Basel altered the stem cells through complex genetic circuits via artificially created – “genetic software”, which was designed to play a role in key growth factors involved in the maturation of cells.

A key role in this process is played by the growth factors Ngn3, Pdx1 and MAFA. The concentration of these factors changed throughout the process of differentiation.
For example, MAFA was absent at the beginning of the process, and appeared only on the fourth day and the final stage, when its concentration increased sharply and remained high.

Changes in the concentration of Ngn3 and Pdx1 followed a rather complex pattern: while Ngn3 concentration increases and then decreases, the level of Pdx1 increases in both early and late maturing.

Fussenegger emphasized it was crucial to attempt the reproduction of natural processes as closely as possible to produce functional beta cells. “Synchronization time and the number of these growth factors is important.”
Fussenegger believes a breakthrough has been made in creating an artificial genetic circuit that has been successfully used in the genetic reprogramming of beta cells. To date, scientists controlled the process of differentiation of stem cells by adding various external chemicals and proteins in the laboratory.

“The challenge is not only to add the required number of components at the right time, but also due to the ineffectiveness of this method, it is impossible to play on a large scale,” Fussenegger said. In contrast, this new method was able to transform the beta cells from three of the stem cells taken from adipose tissue.

The resulting beta cells are not only very similar to their natural counterparts but both species contain secretory granules that store insulin. Artificial beta cells are also functionally very similar to the natural.

“They are now producing not as much insulin as natural beta-cells,” Fussenegger admitted. However, the main achievement of the scientists is they were the first to manage to reproduce the entire sequence of the natural process of differentiation of stem cells in the beta cells.

In the future this new technique may allow Swiss researchers to transplant new functional beta cells in patients with diabetes from their own adipose tissue.
Preliminary transplant beta cells demand the suppression of the immune system of the recipient, as with any transplantation of donated organs or tissue.

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Bioengineering Rehabilitation for Wounded

Regeneration of bone and tissue loss, sustained through mechanical or gunshot wounds through application of ilaya.regeneration stem cell technology

30 520 391 UAH (834 606 USD) needed
100% raised
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Миколаївський обласний благодійний фонд “РЕГІОНАЛЬНИЙ ФОНД БЛАГОЧЕСТЯ”
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Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBANcode: UA703052990000026002041702959
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: Commerzbank AG ,Frankfurt am Main, Germany
Swift code: COBADEFF
Correspondent account: 400886700401
Description: Charitable donation for ‘’ project
PLZ
Beneficiary: Mykolayiv Regional Charitable Foundation "Regional Foundation Blagochestya"
IBAN Code: UA363052990000026006001705679
Name of the bank: JSC CB "PRIVATBANK", 1D HRUSHEVSKOHO STR., KYIV, 01001, UKRAINE
Bank SWIFT Code: PBANUA2X
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
CORRESPONDENT BANK: Bank Pekao/Grupa Pekao S.A., Warsaw, Poland
Account in the correspondent bank: PL13124000013140533111120301
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GBP
Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBANcode: UA583052990000026007011702069
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: JP Morgan Chase Bank,New York ,USA
Swift code: CHASUS33
Correspondent account: 001-1-000080
Description: Charitable donation for ‘’ project
or
Intermediary bank: The Bank of New York Mellon, New York, USA
Swift code: IRVT US 3N
Correspondent account: 890-0085-754
Description: Charitable donation for ‘’ project

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