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Bioengineering Rehabilitation for Wounded

Using stem cell technology for regeneration of damaged tissue

A transplantation material has been developed that gradually releases stem cells to repair damaged tissue.

Cell therapy is a promising method of regenerating damaged tissue, but the method for the input of the cells thus far works poorly, leading to low survival rate of or scattering of the transplanted stem cells, meaning that the effectiveness at the site of injury is not enough for the desired clinical effect.

American scientists from the Georgia Institute of Technology have developed a biodegradable injectable alginate hydrogel that allows for the release and distribution of stem cells used to regenerate bone tissue at a gradual rate. The proposed material takes the form of balls with a diameter <200μm, which may be introduced at the site of the damage and remain there for a long time until they undergo biodegradation, and the cells distributed from the balls remain viable. Scientists have proposed the gradual release of cells from alginate micro beads added to an alginate-lyase hydrogel. The balls are formed using a high electrostatic potential, and their controlled biodegradation achieved through a combination of alginate-lyase and alginate at 4 ° C. The results showed that the rate of degradation of micro balls and the release of cells depended on the ratio of the content of alginate hydrogels and alginate-lyase. The viability of cells being released from the balls ranged from 87% the day after transplantation and up to 71% – on the 12th day. Cultured cells grown in an osteogenic medium produced higher levels of osteocalcin and similar levels of other soluble factors as cells that were neither previously encapsulated nor exposed to alginate-lyase. Also increased in the released were levels of Bmp2, Fgf2, and Vegfa mRNA. Thus, under the proposed release system, stem cells can be controlled to produce viable cells and the osteogenic growth factors later can be modulated.

Research materials are presented in this article; http://www.ncbi.nlm.nih.gov/pubmed/23906513

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Bioengineering Rehabilitation for Wounded

Regeneration of bone and tissue loss, sustained through mechanical or gunshot wounds through application of ilaya.regeneration stem cell technology

30 520 391 UAH (834 606 USD) needed
100% raised
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Реквізити ПриватБанку для переказу у гривнях
Миколаївський обласний благодійний фонд “РЕГІОНАЛЬНИЙ ФОНД БЛАГОЧЕСТЯ”
ПАО КБ ПриватБанк
ЄДРПОУ: 36143302
МФО: 305299
IBAN-код:
Призначення платежу: Благодійний внесок. “”
USD
Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBANcode: UA583052990000026007011702069
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: JP Morgan Chase Bank,New York ,USA
Swift code: CHASUS33
Correspondent account: 001-1-000080
Description: Charitable donation for ‘’ project
or
Intermediary bank: The Bank of New York Mellon, New York, USA
Swift code: IRVT US 3N
Correspondent account: 890-0085-754
Description: Charitable donation for ‘’ project
EUR
Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBANcode: UA703052990000026002041702959
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: Commerzbank AG ,Frankfurt am Main, Germany
Swift code: COBADEFF
Correspondent account: 400886700401
Description: Charitable donation for ‘’ project
PLZ
Beneficiary: Mykolayiv Regional Charitable Foundation "Regional Foundation Blagochestya"
IBAN Code: UA363052990000026006001705679
Name of the bank: JSC CB "PRIVATBANK", 1D HRUSHEVSKOHO STR., KYIV, 01001, UKRAINE
Bank SWIFT Code: PBANUA2X
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
CORRESPONDENT BANK: Bank Pekao/Grupa Pekao S.A., Warsaw, Poland
Account in the correspondent bank: PL13124000013140533111120301
SWIFT Code of the correspondent bank: PKOPPLPW
Description: Charitable donation for "" project.
GBP
Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBANcode: UA583052990000026007011702069
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: JP Morgan Chase Bank,New York ,USA
Swift code: CHASUS33
Correspondent account: 001-1-000080
Description: Charitable donation for ‘’ project
or
Intermediary bank: The Bank of New York Mellon, New York, USA
Swift code: IRVT US 3N
Correspondent account: 890-0085-754
Description: Charitable donation for ‘’ project

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