Broad-spectrum antibiotics can destroy the intestinal microflora, adversely affecting the transplantation of allogeneic (donor) stem cells.
These are the results of a recent study involving 857 patients, published in Science Translational Medicine.
According to scientists, the “good” bacteria protect against the development of graft-versus-host reaction (RTPH) that occurs when transplanting genetically non-identical donor cells through the activity of the immune system of the recipient. Antibiotics in this case can harm. On the other hand, transplant patients are vulnerable to deadly bacterial infections and require broad spectrum treatment
To better understand the impact of antibiotics on the risk of RTPH and the success of stem cell transplantation Yusuke Shono, Melissa Docampo and colleagues analyzed 857 medical records of patients who underwent transplantation of allogeneic hematopoietic cells. Scientists compared the names and doses of antibiotics to cases of complications.
In addition, to the authors, samples of feces were available, which can determine the microbial diversity of the intestinal microflora each patient after treatment with antibiotics. Additional experiments were conducted with stem cell transplantation in mice who were given broad-spectrum antibiotics.
Experiments have confirmed that this antibiotic, which scientists compared to carpet bombing, often leads to RTPH. Although the work of Dr Shono is preliminary and requires serious verification, some experts believe that it is “very alarming”, which should not be ignored by doctors.
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