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Bioengineering Rehabilitation for Wounded

Scientists from US discover means of fighting leukemia

Oncologists at the University of Cincinnati (UC), have discovered a signal path in the micro-RNA MIR-22 compound that helps cure acute myeloid leukemia – the most common type of cancer of the blood and bone marrow. The results of this research were published on April 26 in the new issue of the journal “Nature Communications”.
Acute myeloid leukemia (AML) – is the most common type of acute leukemia which occurs when the bone marrow begins to create blasts of genetic changes which “freeze” cells in an immature state. These malignancies usually provoke a proliferation of altered white blood cells. Accumulating in the bone marrow, they inhibit the growth of normal blood cells, leading to a reduction in the number of red blood cells, platelets, and normal white blood cells. The disease manifests itself in rapid fatigue, shortness of breath, frequent minor skin lesions, increased bleeding, and frequent infected lesions.
Associate professor of cancer biology at UC College of Medicine and lead study author Jianjun Chen said micro-RNAs play a key role in cancer development.
“Micro-RNAs constitute a class of small non-coding cells inside RNA that control the genes –  enhance their activity, or inhibit (suppress) and minimize their functions. Thus cellular mRNA are organisms used to transfer genetic information,” Chen said.
Previous studies have shown that miR-22 is associated with breast cancer and blood diseases that sometimes precede leukemia. However Chen’s team in the study found that this molecule can be a powerful anticancer tool. If it intensifies the activity of the gene responsible for synthesis of miR-22, the leukemia cells begin to experience difficulties in development, growth and reproduction. This type of microRNA inhibits the function of certain genes associated with cancer (crtc1, FLT3 and MYCBP) and blocks metabolic pathways that contribute to the disease.
The development of leukemia is caused by the loss of DNA responsible for the synthesis of miR-22. As the scientists discovered in experiments with mice, it can be stopped if you insert into the bone marrow cells with nanoparticle DNA oligonucleotides (nucleic acid molecules) that carry miRNAs.
“Typically, most patients with acute myeloid leukemia live not longer than five years, even with the use of chemotherapy. Therefore, the development of new effective treatments for cancer based on the basic mechanisms of the disease is necessary,” the researchers concluded.

Original article here.

The project Bioengineering Rehabilitation for Wounded has proved its effectiveness for the past 18 months. For our wards, this advanced technology has been the only way to avoid disability and physical limitations. The number of men who have been put on back on their feet by the project’s doctors is growing. However, there are many more wounded military personnel in need of this specialist medical care that can not be provided in public institutions, and sometimes not even abroad. So once again we ask you to get involved in fundraising and support Ukraine’s military.

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Bioengineering Rehabilitation for Wounded

Regeneration of bone and tissue loss, sustained through mechanical or gunshot wounds through application of ilaya.regeneration stem cell technology

30 520 391 UAH (834 606 USD) needed
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Реквізити ПриватБанку для переказу у гривнях
Миколаївський обласний благодійний фонд “РЕГІОНАЛЬНИЙ ФОНД БЛАГОЧЕСТЯ”
ПАО КБ ПриватБанк
ЄДРПОУ: 36143302
МФО: 305299
IBAN-код:
Призначення платежу: Благодійний внесок. “”
USD
Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBANcode: UA583052990000026007011702069
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: JP Morgan Chase Bank,New York ,USA
Swift code: CHASUS33
Correspondent account: 001-1-000080
Description: Charitable donation for ‘’ project
or
Intermediary bank: The Bank of New York Mellon, New York, USA
Swift code: IRVT US 3N
Correspondent account: 890-0085-754
Description: Charitable donation for ‘’ project
EUR
Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBANcode: UA703052990000026002041702959
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: Commerzbank AG ,Frankfurt am Main, Germany
Swift code: COBADEFF
Correspondent account: 400886700401
Description: Charitable donation for ‘’ project
PLZ
Beneficiary: Mykolayiv Regional Charitable Foundation "Regional Foundation Blagochestya"
IBAN Code: UA363052990000026006001705679
Name of the bank: JSC CB "PRIVATBANK", 1D HRUSHEVSKOHO STR., KYIV, 01001, UKRAINE
Bank SWIFT Code: PBANUA2X
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
CORRESPONDENT BANK: Bank Pekao/Grupa Pekao S.A., Warsaw, Poland
Account in the correspondent bank: PL13124000013140533111120301
SWIFT Code of the correspondent bank: PKOPPLPW
Description: Charitable donation for "" project.
GBP
Beneficiary: Mykolayiv Regional Charitable Foundation “Regional Foundation Blagochestya”
IBANcode: UA583052990000026007011702069
Beneficiary address: UA 54000, Mykolaiv, Buznyka str. 5, 118
Beneficiary bank: Privatbank
50, Naberezhna Peremogy Street, Dnipropetrovsk, 49094, Ukraine
Swift code: PBANUA2X

Intermediary bank: JP Morgan Chase Bank,New York ,USA
Swift code: CHASUS33
Correspondent account: 001-1-000080
Description: Charitable donation for ‘’ project
or
Intermediary bank: The Bank of New York Mellon, New York, USA
Swift code: IRVT US 3N
Correspondent account: 890-0085-754
Description: Charitable donation for ‘’ project

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