Currently, scientists and doctors are searching for an effective treatment for acute lung injury caused by pneumonia. It has been proven adipose tissue derived from adult stem cells has an anti-inflammatory and antibacterial effect.
Chinese scientists from Zhejiang University, the East China Pedagogical University and Hangzhou University in a study rated the therapeutic effect of stem cells on lesions of the lungs caused by Staphylococcus aureus. The work was carried out on laboratory mice.
It was proven that an intra-tracheal injection of adipose tissue derived from stem cells reduced the severity of inflammation in the lungs and reduced the bacterial load. This led to a significant reduction in mortality among infected animals.
The experiments also revealed the mechanism of the protective action of stem cells. It was found the secretion of regenerating islet-derived IIIγ (RegIIIγ) is responsible for the protective effect of ADSCs. Moreover, the expression of RegIIIγ requires TLR2, MyD88, and JAK2/STAT3 activation.